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Potential therapeutic effects of branched-chain amino acids supplementation on resistance exercise-based muscle damage in humans

Claudia R da Luz1*, Humberto Nicastro1, Nelo E Zanchi12, Daniela FS Chaves1 and Antonio H Lancha1

Author Affiliations

1 Laboratory of Applied Nutrition and Metabolism, School of Physical Education and Sports, University of São Paulo, São Paulo, SP, Brazil

2 Institute of Biomedical Science, University of São Paulo, São Paulo, SP, Brazil

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Journal of the International Society of Sports Nutrition 2011, 8:23  doi:10.1186/1550-2783-8-23

Published: 14 December 2011


Branched-chain amino acids (BCAA) supplementation has been considered an interesting nutritional strategy to improve skeletal muscle protein turnover in several conditions. In this context, there is evidence that resistance exercise (RE)-derived biochemical markers of muscle soreness (creatine kinase (CK), aldolase, myoglobin), soreness, and functional strength may be modulated by BCAA supplementation in order to favor of muscle adaptation. However, few studies have investigated such effects in well-controlled conditions in humans. Therefore, the aim of this short report is to describe the potential therapeutic effects of BCAA supplementation on RE-based muscle damage in humans. The main point is that BCAA supplementation may decrease some biochemical markers related with muscle soreness but this does not necessarily reflect on muscle functionality.

Leucine; Delayed onset muscle soreness; Creatine kinase; Protein turnover